Angiogenesis is the mechanism by which new blood vessels develop from a pre-existing vasculature. This has great importance for wound healing and tissue regeneration but is also a primary mechanism for cancer development. Other than for tissue repair, angiogenesis is not primarily required for homeostasis and survival of normal healthy adults. Thus inhibition of angiogenesis is potentially a useful goal for prevention of cancer development without the many adverse non-specific effects linked to traditional anti-cancer drugs.
How angiogenic events and endothelial cells vary between health and disease is not fully understood. In particular, I am fascinated by the way endothelial cells are transformed by surrounding tissue matrix conditions, and how they in turn modify their own matrix microenvironment. As a variable that clearly delineates physiological and pathological microenvironments, the interaction of endothelial cells with their surroundings may reveal novel aspects of angiogenesis and potentially provide new avenues for therapeutic intervention. This interest has led my research down several distinct pathways.
If interested in any of these projects, please contact me at the address below.
At this time there are no funded external openings in the laboratory; however, please feel free to contact me at the address below if interested in any of the laboratory research.